The regiment was formed 31 January 1761 in South Carolina by Ralph Burton from a number of recently raised independent companies that had arrived from New York in November 1760. From nine companies of about 100 men each, Burton created a regiment consisting of ten companies each about 75 men strong. The regiment seems to have been in the field by May 1961, near Fort Prince George. 
The regiment fought successfully against the Cherokees in the Anglo-Cherokee War. It then transferred to Barbados. From there it participated in the capture of Martinique, the occupation of Grenada, and the 1762 Battle of Havana. The regiment was badly depleted. In October 1762, the regiment's privates were moved into other regiments stationed in Havana; its officers and NCOs were sent to England. The war having ended before new men could be recruited, the regiment was disbanded on 7 March 1763.
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